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The dynamical roles of miR-17-92 on the E2F-related network during the G1/S transition

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成果类型:
期刊论文
作者:
He, Peng;Billy, Kirunda John;Ma, Huishu;Jia, Ya(贾亚);Yang, Lijian*
通讯作者:
Yang, Lijian
作者机构:
[Jia, Ya; Ma, Huishu; He, Peng; Yang, Lijian; Billy, Kirunda John] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Hubei, Peoples R China.
[Jia, Ya; Ma, Huishu; He, Peng; Yang, Lijian; Billy, Kirunda John] Cent China Normal Univ, Dept Phys, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Yang, Lijian] C
Cent China Normal Univ, Inst Biophys, Wuhan 430079, Hubei, Peoples R China.
Cent China Normal Univ, Dept Phys, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
关键词:
Nonlinear dynamic analysis;Bifurcation;Biological network;Fluctuation;microRNA;Cell cycle
期刊:
Nonlinear Dynamics
ISSN:
0924-090X
年:
2019
卷:
95
期:
1
页码:
259-271
基金类别:
Acknowledgements This work was supported by the National Natural Science Foundation of China under 11775091 and 11474117(Ya Jia) and self-determined research funds of CCNU from the colleges’ basic research and operation of MOE, NO. CCNU18QN035 (Lijian Yang). This work was supported by the National Natural Science Foundation of China under 11775091 and 11474117(Ya Jia) and self-determined research funds of CCNU from the colleges? basic research and operation of MOE, NO. CCNU18QN035 (Lijian Yang). The authors declare that they have no conflict of interest concerning the publication of this manuscript.
机构署名:
本校为第一且通讯机构
院系归属:
物理科学与技术学院
心理学院
摘要:
E2F is a key transcription factor in the cell cycle network that regulates cell transition from G1 to S phase. MiR-17-92 plays an important role in the expression of E2F and regulates the progression of the cell cycle. Based on the Rb-E2F-MiR cell cycle network, we found that introduction of miR-17-92 in the network prolongs the cell cycle transition from G1 to S phase effectively and also maintains the robustness of the network against fluctuations. The dynamics of E2F are highly nonlinear, and by analysis of the bifurcation diagrams, we found...

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