E2F is a key transcription factor in the cell cycle network that regulates cell transition from G1 to S phase. MiR-17-92 plays an important role in the expression of E2F and regulates the progression of the cell cycle. Based on the Rb-E2F-MiR cell cycle network, we found that introduction of miR-17-92 in the network prolongs the cell cycle transition from G1 to S phase effectively and also maintains the robustness of the network against fluctuations. The dynamics of E2F are highly nonlinear, and by analysis of the bifurcation diagrams, we found...
