Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip

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成果类型：

期刊论文

作者：

Li, Yan;Liu, Yan;Hu, Chuanlin;Chang, Qing;Deng, Qihong;...

通讯作者：

Yang, Xu;Wu, Yang

作者机构：

[Liu, Yan; Wu, Yang; Li, Yan] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Chinese Minist Educ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

[Hu, Chuanlin] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Peoples R China.

[Yang, Xu; Deng, Qihong] Cent South Univ, XiangYa Sch Publ Hlth, Changsha 410083, Peoples R China.

[Chang, Qing] Hong Kong Univ Sci & Technol, Dept Chem & Biomol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Sch Life Sci, Lab Environm Biomed, Wuhan 430079, Peoples R China.

通讯机构：

[Yang, Xu] C

[Wu, Yang] W

Cent China Normal Univ, Sch Life Sci, 152 Luo Yu Rd, Wuhan 430079, Peoples R China.

Wuhan Polytech Univ, Coll Food Sci & Engn, 68 Xuefu South Rd, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Indoor nanoscale particulate matter;3D microfluidic chip;blood-brain barrier;Oxidative stress;Nrf2/Keap1 signal pathway

期刊：

Environment International

ISSN：

0160-4120

年：

2020

卷：

143

页码：

105598

DOI：

10.1016/j.envint.2020.105598

基金类别：

This work was supported by Key Project of Department of Education Hubei province China (No. D20181806 ).

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Background: There is growing public awareness regarding the health effects of indoor nanoscale particulate matter (INPM) since people spend the majority of their time indoors. INPM could have a direct entry route into the brain via the axons of the olfactory nerve and migrating across the blood-brain barrier (BBB). Using animals to explore this possibility is not a reliable method to fully demonstrate human physiological responses. We, therefore, set out to develop a human 3D functional blood-brain barrier model to examine the potential effects...

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Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip

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