版权说明 操作指南
首页 > 成果 > 详情

Stereoselective Synthesis of 12-Tetrazolyl Substituted (E)-5H-Quinazolino[3,2-a]quinazolines via Sequential Ugi-Azide/Staudinger/aza-Wittig/Addition/Ag(I)-Catalyzed Cyclization

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Yang, Mao-Lin;Zhao, Long;Chen, Hao-Ran;Ding, Ming-Wu
通讯作者:
Ding, MW
作者机构:
[Ding, MW; Yang, Mao-Lin; Chen, Hao-Ran; Ding, Ming-Wu; Zhao, Long] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Ding, MW ] C
Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Hubei Int Sci & Technol Cooperat Base Pesticide &, Minist Educ, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
Catalysis;Potash;Reaction intermediates;Silver compounds;Stereoselectivity;Alkynyls;Cyclizations;Efficient synthesis;Isocyanides;Quinazolines;Stereoselective synthesis;Trimethylsilyl azide;Triphenyl phosphines;]+ catalyst;Cyclization;12 (1 cyclohexyl 1h tetrazol 5 yl) 5 (4 methylbenzylidene) 6 (para tolyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;12 tetrazolyl 5h quinazolino[3,2 a]quinazoline derivative;12 [1 (tert butyl) 1h tetrazol 5 yl] 5 (4 methylbenzylidene) 6 (para tolyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (4 chlorophenyl) 5 (4 methylbenzylidene) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (4 methoxyphenyl) 5 (4 methylbenzylidene) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (4 methoxyphenyl) 5 pentylidene 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;2 (alkynyl)benzenamine;2 azidobenzaldehyde;5 benzylidene 12 (1 butyl 1h tetrazol 5 yl) 6 (4 methoxyphenyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 3 chloro 6 cyclohexyl 6,12 dihydro 5h quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 3 methyl 6 (para tolyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 3 methyl 6 propyl 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (4 methoxyphenyl) 10 methyl 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (4 methoxyphenyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 6 (para tolyl) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 12 [1 (tert butyl) 1h tetrazol 5 yl] 6 cyclohexyl 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 6 butyl 12 [1 (tert butyl) 1h tetrazol 5 yl] 10 methyl 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 6 butyl 12 [1 (tert butyl) 1h tetrazol 5 yl] 3 methyl 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;5 benzylidene 6 butyl 12 [1 (tert butyl) 1h tetrazol 5 yl] 9 chloro 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;6 butyl 12 [1 (tert butyl) 1h tetrazol 5 yl] 5 (4 methylbenzylidene) 6,12 dihydro 5h quinazolino[3,2 a]quinazoline;azide;heterocyclic compound;isocyanate;isocyanide;n [(2 azido 4 chlorophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 2 (phenylethynyl)aniline;n [(2 azido 5 methylphenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 2 (phenylethynyl)aniline;n [(2 azidophenyl)(1 butyl 1h tetrazol 5 yl)methyl] 2 (phenylethynyl)aniline;n [(2 azidophenyl)(1 butyl 1h tetrazol 5 yl)methyl] 4 chloro 2 (phenylethynyl)aniline;n [(2 azidophenyl)(1 cyclohexyl 1h tetrazol 5 yl)methyl] 2 (para tolylethynyl)anilin;n [(2 azidophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 2 (hex 1 yn 1 yl)aniline;n [(2 azidophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 2 (para tolylethynyl)aniline;n [(2 azidophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 2 (phenylethynyl)aniline;n [(2 azidophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 4 chloro 2 (phenylethynyl)aniline;n [(2 azidophenyl)[1 (tert butyl) 1h tetrazol 5 yl]methyl] 4 methyl 2 (phenylethynyl)aniline;quinazoline derivative;silver;tetrazole derivative;trimethylsilyl azide;triphenylphosphine;unclassified drug;addition reaction;Article;asymmetric synthesis;catalysis;cyclization;drug structure;drug synthesis;isomerization;nuclear magnetic resonance spectroscopy;reaction analysis;room temperature;Staudinger reaction;stereoselectivity;substitution reaction;ugi azide reaction;Wittig reaction;X ray diffraction
期刊:
JOURNAL OF ORGANIC CHEMISTRY
ISSN:
0022-3263
年:
2023
卷:
88
期:
3
页码:
1898-1906
基金类别:
We gratefully acknowledge financial support of this work by the National Natural Science Foundation of China (No. 21572075) and the 111 Project B17019.
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A new efficient and stereoselective synthesis of 12-tetrazolyl substituted (E)-5H-quinazolino[3,2-a]quinazolines via sequential Ugi-azide/Staudinger/aza-Wittig/addition/Ag(I)-catalyzed cyclization was developed. The four-component reactions of 2-azidobenzaldehyde, 2-(alkynyl)benzenamine, isocyanide, and trimethylsilyl azide gave Ugi-azide intermediates, which were subsequently treated with triphenylphosphine and isocyanate to produce 12-tetrazolyl substituted (E)-5H-quinazolino[3,2-a]quinazolines in the presence of...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com