期刊论文

Zhang, Dan;Yang, GF

英文

Redox Biology

2213-2317

2023

63

102751

10.1016/j.redox.2023.102751

National Key Research and Development Program of China [2017YFA0505203]; National Natural Science Foundation of China [21877045]; 111 Program [B17019]; Chemical Biology Center, College of Chemistry, Central China Normal University

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Catalase (CAT) is an important antioxidant enzyme that breaks down H(2)O(2) into water and oxygen. Inhibitor-modulating CAT activity in cancer cells is emerging as a potential anticancer strategy. However, the discovery of CAT inhibitors towards the heme active center located at the bottom of long and narrow channel has made little progress. Therefore, targeting new binding site is of great importance for the development of efficient CAT inhibitors. Here, the first NADPH-binding site inhibitor of CAT, BT-Br, was designed and synthesized success...