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Formamidine hydrochloride as an amino surrogate: I2-catalyzed oxidative amidation of aryl methyl ketones leading to free (N–H) α-ketoamides

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成果类型:
期刊论文
作者:
Liu, Shan;Gao, Qinghe;Wu, Xia;Zhang, Jingjing;Ding, Kerong;...
通讯作者:
Wu, Anxin
作者机构:
[Wu, Anxin; Zhang, Jingjing; Liu, Shan; Gao, Qinghe; Ding, Kerong; Wu, Xia] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
[Wu, Anxin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, Anxin] C
Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
语种:
英文
期刊:
Organic & Biomolecular Chemistry
ISSN:
1477-0520
年:
2015
卷:
13
期:
8
页码:
2239-2242
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21272085, 21472056]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A highly efficient molecular iodine catalyzed oxidative amidation of aryl methyl ketones with formamidine hydrochloride has been developed. This reaction represents a novel strategy for the synthesis of free (N-H) alpha-ketoamides. Based on the experimental results, a self-sequenced iodination/Kornblum oxidation/amidation/oxidation...

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