Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway

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成果类型：

期刊论文

作者：

Duan, Liju;Li, Jinquan;Ma, Ping;Yang, Xu;Xu, Shunqing*

通讯作者：

Xu, Shunqing

作者机构：

[Xu, Shunqing; Duan, Liju] Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.

[Xu, Shunqing; Duan, Liju] Huazhong Univ Sci & Technol, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.

[Xu, Shunqing; Duan, Liju] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan 430030, Hubei, Peoples R China.

[Li, Jinquan; Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Sect Environm Biomed, Wuhan 430079, Hubei, Peoples R China.

[Ma, Ping] Hubei Univ Sci & Technol, Sch Basic Med Sci, Res Ctr Basic Med Sci, Xianning 437100, Peoples R China.

通讯机构：

[Xu, Shunqing] H

Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan 430030, Hubei, Peoples R China.

语种：

英文

关键词：

Ozone;Vitamin E;Oxidative stress;Allergic asthma;Nrf2 pathway

期刊：

Food and Chemical Toxicology

ISSN：

0278-6915

年：

2017

卷：

107

期：

Pt A

页码：

47-56

DOI：

10.1016/j.fct.2017.06.025

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81302402]; National Natural Science Foundation of China- Key ProgramNational Natural Science Foundation of China (NSFC) [21577045]; Hubei Province health and family planning scientific research project [WJ2017Z027]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Millions of people are regularly exposed to ozone, a gas known to contribute significantly to worsening the symptoms of patients with asthma. However, the mechanisms underlying these ozone exacerbation effects are not fully understood. In this study, we examined the exacerbation effect of ozone in OVA induced asthma mice and tried to demonstrate the protective mechanism of vitamin E (VE). An asthma mouse model was established, and used to identify the exacerbating effects of ozone by assessing cytokine and serum immunoglobulin concentrations, airway leukocyte infiltration, histopathological ch...

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Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway

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