It has become increasingly crucial to implement the precise determination of hydrogen sulfide (H2S) in biosystems since the abnormal level of H2S may induce various diseases. However, due to the high volatility and fast catabolism of H2S, traditional H2S detection methods are confronted with great challenges. Fortunately, the development of optical nanotechnology sheds new light on the real-time and sensitive detection of intracellular or subcellular H2S. Nanomaterials emerged as potential candidates for the optical detection of biomolecule analytes due to their excellent properties, such as e...