期刊论文

Yang, Guang-Fu（杨光富）

英文

Bioorganic & Medicinal Chemistry

0968-0896

2007

15

4

1716-1724

10.1016/j.bmc.2006.12.002

We thank Dr. Jie Chen for the test of biological activity. We also thank the financial support from the National Key Project for Basic Research (2003CB114400), National NSFC (Nos. 20572030, 20432010, and 20528201), Key project of Ministry of Education (Nos. 103116 and 104205), Foundation for Ph.D. (20060511003), and Program for Excellent Research Group of Hubei Province (No. 2004ABC002).

本校为第一且通讯机构

In order to discover lead compounds with novel action mechanism, a series of tetrazolinone derivatives bearing structurally diverse substituents, 1-aryl-4-substituted-1,4-di-hydro-5H-tetrazol-5-ones 2, 1-((5-(alkylthio)-1,3,4-oxadiazol-2-yl)methyl)-4-(substituted)- phenyl-1H-tetrazol-5(4H)-ones 5, and 1-((5-(alkylthio)-1,3,4-thiadiazol-2-yl)methyl)-4- (substituted)phenyl-1H-tetrazol-5(4H)-ones 7, were designed and synthesized in good yields by a multiple-step synthetic procedure. The results of greenhouse in vivo test indicated that all the tar...