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Autism spectrum disorder-like behavior induced in rat offspring by perinatal exposure to di-(2-ethylhexyl) phthalate

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成果类型:
期刊论文
作者:
Li, Yao;Zhao, Yun;Lu, Yu;Lu, Xianxian;Hu, Yingdan;...
通讯作者:
Li, R
作者机构:
[Li, R; Li, Yao; Li, Qiulin; Hu, Yingdan; Li, Rui; Shuai, Menglei; Zhao, Yun; Lu, Xianxian; Lu, Yu] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
[Li, Yao] Huazhong Agr Univ, Off Youth League Comm, Wuhan 430070, Peoples R China.
[Lu, Yu] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China.
通讯机构:
[Li, R ] C
Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
DEHP;ASD-like behavior;mTOR signaling pathway;Autophagy
期刊:
Environmental Science and Pollution Research
ISSN:
0944-1344
年:
2022
卷:
29
期:
34
页码:
52083-52097
基金类别:
This research is financially supported by the National Natural Science Foundation of China (42077403) and Self-Determined Research Funds of CCNU from the Colleges’ Basic Research and Operation of MOE (CCNU18JCXK07 and CCNU19TS066).
机构署名:
本校为第一且通讯机构
院系归属:
生命科学学院
摘要:
Autism spectrum disorders (ASD), also known as childhood autism, is a common neurological developmental disorder. Although it is generally believed that genetic factors are a primary cause for ASD development, more and more studies show that an increasing number of ASD diagnoses are related to environmental exposure. Epidemiological studies indicated that perinatal exposure to endocrine disruptors might cause neurodevelopmental disorders in children. Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in many products. To explore...

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