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pH-Sensitive and Biodegradable Mn-3(PO4)(2)center dot 3H(2)O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

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成果类型:
期刊论文
作者:
Zhou, Shi-Hao;Zhang, Ru-Yan;You, Zi-Wei;Zou, Yong-Ke;Wen, Yu;...
通讯作者:
Yang, G.-F.;Guo, J.
作者机构:
[Wang, Jian; Zhang, Zhi-Ming; Yang, Guang-Fu; Bian, Miao-Miao; Yuan, Hong; Zhang, Ru-Yan; Ding, Dong; Wen, Yu; Guo, Jun; Zhou, Shi-Hao; You, Zi-Wei; Zou, Yong-Ke] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Guang-Fu Yang; Jun Guo] K
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China
语种:
英文
关键词:
manganese phosphate;manganese adjuvant;bivalent vaccine;SARS-CoV-2;Omicron variant
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2023
卷:
15
期:
7
页码:
8914-8926
基金类别:
This work was supported by the National Natural Science Foundation of China (22177035, 21772056), the National Key Research and Development Program of China (2017YFA0505200), Wuhan Bureau of Science and Technology (2020020601012217), the Fundamental Research Funds for the Central Universities (CCNU22JC007, CCNU20TS016), and Program of Introducing Talents of Discipline to Universities of China (111 program, B17019).
机构署名:
本校为第一机构
院系归属:
化学学院
摘要:
Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of great significance to enhance vaccine efficacy. In this work, we prepared a long-term stable, pH-sensitive, and biodegradable Mn(3)(PO(4))(2)·3H(2)O nanoparticle (nano-MnP) by simply mixing MnCl(2)/NaH(2)PO(4)/Na(2)HPO(4) solution for the first time and employed it as an immune stimulant in the bivalent COVID-19 protein vaccine comprised of wild-type S1 (S1-WT) and Omicron S1 (S1-Omicron) proteins as antigens to elicit a broad-spectrum imm...

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