期刊论文

Tong, Zhiqian;Song, Weihong

英文

FASEB JOURNAL

0892-6638

2018

32

7

3669-3679

10.1096/fj.201701239R

This work was supported by grants from the Natural Science Foundation of China (NSFC; 81400874, 31171080, and 51136002), the Scientific Research Common Program of the Beijing Municipal Commission of Education (KM201510025014), the Natural Scientific Foundation of Capital Medical University (CCMU; 2015ZR31), and the Beijing Institute for Brain Disorders (0000040103 and ZD2015-08). W.S. is the holder of the Tier 1 Canada Research Chair in Alzheimer’s Disease. Y.Z. is the recipient of the Michael Smith Foundation for Health Research/The Pacific Alzheimer Research Foundation Post-Doctoral Fellowship Award. The authors declare no conflicts of interest.

本校为其他机构

Patients with type 2 diabetes mellitus (T2DM) often develop cognitive impairments and have an increased risk of developing Alzheimer's disease. Hyperglycemia is a major characteristic of T2DM, but how elevated glucose levels lead to cognitive decline remains elusive. Here, we report that patients with T2DM and mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase 2 (ALDH2) gene had higher levels of FA and more severe dementia. Injection of FA induced hyperglycemia and cognitive deficits in rats. Ablation of gene expression of ALDH2, the main enzyme to oxidize FA, resulted ...