Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

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成果类型：

期刊论文

作者：

Liu, Xudong;Zhang, Yuchao;Li, Jinquan;Wang, Dong;Wu, Yang;...

通讯作者：

Yang, Xu

作者机构：

[Wu, Yang; Wang, Dong; Li, Jinquan; Li, Rui; Yang, Xu; Zhang, Yuchao; Liu, Xudong] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Lab Environm Biomed, Wuhan 430079, Peoples R China.

[Li, Yan] Hong Kong Univ Sci & Technol, Dept Biomol & Chem Engn, Hong Kong, Hong Kong, Peoples R China.

[Lu, Zhisong] Southwest Univ, Inst Clean Energy & Adv Mat, Chongqing, Peoples R China.

[Yu, Samuel C. T.] Hong Kong Univ Sci & Technol, Div Environm, Hong Kong, Hong Kong, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

通讯机构：

[Yang, Xu] C

Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

behavioral changes;oxidative stress;inflammation;apoptosis

期刊：

INTERNATIONAL JOURNAL OF NANOMEDICINE

ISSN：

1178-2013

年：

2014

卷：

期：

页码：

823-839

DOI：

10.2147/IJN.S56339

基金类别：

Chinese Ministry of EducationMinistry of Education, China; Chongqing Natural Science FoundationNatural Science Foundation of Chongqing [cstc2012jjA1137]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21103059, 51136002]; China Key Technologies RD Program [2012BAJ02B0301]

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

Single-walled carbon nanotubes (SWCNTs) have shown increasing promise in the field of biomedicine, especially in applications related to the nervous system. However, there are limited studies available on the neurotoxicity of SWCNTs used in vivo. In this study, neurobehavioral changes caused by SWCNTs in mice and oxidative stress were investigated. The results of ethological analysis (Morris water maze and open-field test), brain histopathological examination, and assessments of oxidative stress (reactive oxygen species [ROS], malondialdehyde [...

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Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

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