期刊论文

Synthesis,Characterization and Activation of Anti-EAC of 2-Hydroxy-N-Napthalde-ASN-K and Its Cu(Ⅱ),Ni(Ⅱ)Complexes

中文

武汉大学学报(医学版)

1671-8852

1991

02

169-173

本校为第一机构

合成了L-天门冬酰胺席夫碱及其铜(Ⅱ)、镍(Ⅱ)配合物,用元素分析、热重-差热分析、氢核磁共振谱、红外光谱、电子光谱和摩尔电导对这三种化合物进行了表征,结果表明;配体及其铜(Ⅱ)、镍(Ⅱ)配合物化学式分别为 K(C_(15)H_(13)N_2O_4)、Cu(C_(15)H_(14)N_2O_5)、Ni(C_(15)H_(14)N_2O_5),配体存在酮式与亚胺之间的互变,铜(Ⅱ)、镍(Ⅱ)配合物中,配体是以酚羟基的氧、亚胺氮和羟盐中的氧进行配位的,另外还有一分子水参加配位,形成四配位的化合物。在小白鼠身上对上述三种化合物进行了抗EAC 活性试验,结果表明,铜(Ⅱ)配合物的抑癌率为20.6%,配体抑癌率为18.6%,而镍(Ⅱ)配合物有促癌作用。

Schiff base was derived from 2-hydroxy-napthaldehyde and L-ans-K and its Cu (Ⅱ),Ni(Ⅱ)com- plexes have been synthesize and characterized by their elemental analysis,IR,TGA,HNMR,electron spectral studies and molar conductance measurenent.It is concluded that the fomulas of the three com- pounds are K(C_(15)H_(13)N_2O_4),),Cu(C_(15)H_(14)N_2O_5),Ni(C_(15)H_(14)N_2O_5)and the schiff base exists in keto- imine form at room temperature in DMSO.The schiff base coordinated to Cu(Ⅱ),Ni(Ⅱ)as a triden- rate ligand (O-N-O).The structure of the two complexes is sug...