Given a graph G, the mixed graph D-G is obtained from G by orienting some of its edges, where G is called the underlying graph of D-G. Let p(D-G), n(D-G) (resp. P(G), n(G)) be the positive inertia index and negative inertia index of D-G (resp. G). In this paper, we first establish the inequalities -d(G) p(D-G)-p(G)