期刊论文

Lan, Yu;Xiao, Wen-Jing

英文

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

0002-7863

2019

141

1

133-137

10.1021/jacs.8b12095

We are grateful to the National Science Foundation of China (No. 21822103, 21820102003, 21772052, 21772053, 21572074 and 21472057), the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019) and the Natural Science Foundation of Hubei Province (2017AHB047) for support of this research.

本校为第一且通讯机构

An enantioselective [5+2] cycloaddition of vinylethylene carbonates and α-diazoketones was achieved for the first time by merging photoactivation and asymmetric Pd catalysis. The key to the success of this method is the enantioselective trapping of Pd-containing, 1,5-dipolar intermediates by ketenes, a class of reactive C2 synthons, which were generated in an in situ and traceless manner under visible light irradiation. Through this trapping, a variety of 7-membered lactones bearing challenging chiral quaternary stereocenters can be accessed i...