Structural insights into DNA recognition by the BEN domain of the transcription factor BANP

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成果类型：

期刊论文

作者：

Ke Liu;Jin Zhang;Yuqing Xiao;Ally Yang;Xiaosheng Song;...

通讯作者：

Ke Liu<&wdkj&>Jinrong Min

作者机构：

[Ke Liu; Jin Zhang; Yuqing Xiao; Yunxia Chen] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, PR China

[Ally Yang; Timothy R. Hughes] Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

[Xiaosheng Song; Yanjun Li] Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

[Jinrong Min] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, PR China<&wdkj&>Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

通讯机构：

[Ke Liu; Jinrong Min] H

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, PR China<&wdkj&>Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, PR China<&wdkj&>Structural Genomics Consortium and Department of Physiology, University of Toronto, Toronto, Ontario, Canada

语种：

英文

关键词：

BEN domain;BANP;BEND6;DNA methylation;X-ray crystallography

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2023

卷：

299

期：

页码：

104734

DOI：

10.1016/j.jbc.2023.104734

机构署名：

本校为第一且通讯机构

院系归属：

生命科学学院

摘要：

The BEN domain-containing transcription factors regulate transcription by recruiting chromatin-modifying factors to specific chromatin regions via their DNA-binding BEN domains. The BEN domain of BANP has been shown to bind to a CGCG DNA sequence or an AAA-containing matrix attachment regions DNA sequence. Consistent with these in vivo observations, we identified an optimal DNA-binding sequence of AAATCTCG by protein binding microarray, which was also confirmed by our isothermal titration calorimetry and mutagenesis results. We then determined crystal structures of the BANP BEN domain in apo f...

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Structural insights into DNA recognition by the BEN domain of the transcription factor BANP

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