I2‑Promoted Multicomponent Dicyclization and Ring-Opening Sequences: Direct Synthesis of Benzo[e][1,4]diazepin-3-ones via Dual C–O Bond Cleavage

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Geng, Xiao;Wang, Can;Huang, Chun;Zhao, Peng;Zhou, You;...

通讯作者：

Wu, Yan-Dong;Wu, An-Xin

作者机构：

[Huang, Chun; Wang, Can; Zhou, You; Geng, Xiao; Wu, An-Xin; Wu, Yan-Dong; Zhao, Peng] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Wu, YD; Wu, AX] C

Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

期刊：

Organic Letters

ISSN：

1523-7060

年：

2019

卷：

期：

页码：

7504-7508

DOI：

10.1021/acs.orglett.9b02789

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602070, 21472056, 21772051]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [CCNU15ZX002, CCNU18QN011]; 111 ProjectMinistry of Education, China - 111 Project [B17019]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

A novel and efficient formal [4 + 2+1] annulation of aryl methyl ketones and 2-aminobenzyl alcohols for the synthesis of benzo[e][1,4]diazepin-3-ones is reported. This reaction successfully affords diverse seven-membered ring lactams via dual C–O bond cleavage. A preliminary mechanistic study showed that a multicomponent dicyclization and ring-opening sequence might occur, with the introduction of methyl sulfide proposed as the last step. This efficient strategy with mild reaction conditions and a broad substrate ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

I2‑Promoted Multicomponent Dicyclization and Ring-Opening Sequences: Direct Synthesis of Benzo[e][1,4]diazepin-3-ones via Dual C–O Bond Cleavage

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问