Based on the economic data,the paper makes a study on spatial-temporal difference of regional economic pattern of Hubei province from 2000~2011 on a scale of county.Using the methods of spatial autocorrelation and geography detectors, the influencing factors of the regional economic difference of Hubei provice was analysed. The results show that the regional economic difference of Hubei provice goes through a progress from decrese to increase since 2000. The key factors of the regional economic difference are the spatial correlation of counties and economic struc...