Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in Drosophila

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成果类型：

期刊论文

作者：

Chowdhury, Munmun;Li, Chun-Feng;He, Zhen;Lu, Yuzhen;Liu, Xu-Sheng（刘绪生）;...

通讯作者：

Yu, Xiao-Qiang;Strand, Michael R.

作者机构：

[He, Zhen; Yu, Xiao-Qiang; Li, Chun-Feng; Chowdhury, Munmun] Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA.

[Liu, Xu-Sheng; He, Zhen; Yu, Xiao-Qiang; Wang, Yu-Feng] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.

[Yu, Xiao-Qiang; Lu, Yuzhen] South China Normal Univ, Guangzhou Key Lab Insect Dev Regulat & Applicat R, Inst Insect Sci & Technol, Guangzhou 510631, Guangdong, Peoples R China.

[Yu, Xiao-Qiang; Lu, Yuzhen] South China Normal Univ, Sch Life Sci, Guangzhou 510631, Guangdong, Peoples R China.

[Li, Chun-Feng] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400716, Peoples R China.

通讯机构：

[Yu, Xiao-Qiang; Strand, Michael R.] U

Univ Missouri, Sch Biol Sci, Div Cell Biol & Biophys, Kansas City, MO 64110 USA.

Univ Georgia, Dept Entomol, Athens, GA 30602 USA.

语种：

英文

关键词：

Spatzle;antimicrobial peptide (AMP);cytokine response;gene regulation;insect immunity;sex-specific difference;signal transduction;toll receptor

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2019

卷：

294

期：

页码：

10172-10181

DOI：

10.1074/jbc.RA118.006804

基金类别：

University of Missouri-Kansas City Funding for Excellence; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472019]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

The Toll signaling pathway in Drosophila melanogaster regulates several immune-related functions, including the expression of antimicrobial peptide (AMP) genes. The canonical Toll receptor (Toll-1) is activated by the cytokine Spätzle (Spz-1), but Drosophila encodes eight other Toll genes and five other Spz genes whose interactions with one another and associated functions are less well-understood. Here, we conducted in vitro assays in the Drosophila S2 cell line with the Toll/interleukin-1 receptor (TIR) homology domains of each Toll family m...

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Toll family members bind multiple Spätzle proteins and activate antimicrobial peptide gene expression in Drosophila

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