Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor

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成果类型：

期刊论文

作者：

Li, Xi;Wei, Qingpeng;Zhao, Kaiyuan;Wang, Weibo;Liu, Bingjie;...

通讯作者：

Wang, J

作者机构：

[Liu, Bingjie; Zhao, Kaiyuan; Wei, Qingpeng; Wang, Weibo; Li, Wenzhe; Wang, Jing; Li, Xi] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.

[Liu, Bingjie; Zhao, Kaiyuan; Wei, Qingpeng; Wang, Weibo; Li, Wenzhe; Wang, Jing; Li, Xi] Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China.

[Wang, Weibo] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.

通讯机构：

[Wang, J ] P

Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.

Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100191, Peoples R China.

语种：

英文

关键词：

IP6;fluorescence biosensor;imaging;IP6Ks;DIPP

期刊：

ACS SENSORS

ISSN：

2379-3694

年：

2023

卷：

期：

页码：

4484-4493

DOI：

10.1021/acssensors.3c00268

基金类别：

National Natural Science Foundation of China [5-IP8]; National Basic Research Foundation of China [2022YFC3400600]; National Natural Science Foundation of China [22277001, 91853107]; Youth Thousand-Talents Program of China; Large-scale Instrument Platform of the State Key Laboratory of Natural and Biomimetic Drugs

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

Inositol hexakisphosphate (IP6), a naturally occurring metabolite of inositol with specific functions in different organelles or tissues, participates in numerous physiological processes and plays a key role in mammalian metabolic regulation. However, current IP6 detection methods, i.e., high-performance liquid chromatography and gel electrophoresis, require sample destruction and lack spatiotemporal resolution. Here, we construct and characterize a genetically encoded fluorescence biosensor named HIPSer that enables ratiometric quantitative IP6 detection in HEK293T cells and subcellular compa...

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Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor

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