The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility.

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xuan Zhuang;Jun Ruan;Canquan Zhou;Zhiming Li

通讯作者：

Zhou, Canquan;Li, Zhiming

作者机构：

[Xuan Zhuang] Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China

[Xuan Zhuang] Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, 363000, China

[Xuan Zhuang] Department of Urology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China

[Jun Ruan] College of Life Sciences, Central China Normal University, Wuhan, Hubei, 430079, China

[Canquan Zhou] Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong Provincial Clinical Research Center for obstetrical and gynecological diseases, Center for Reproductive Medicine and Department of Gynecology & Obstetrics, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. zhoucanquan@mail.sysu.edu.cn

通讯机构：

[Zhou, Canquan] G

[Li, Zhiming] I

Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangdong Provincial Clinical Research Center for obstetrical and gynecological diseases, Center for Reproductive Medicine and Department of Gynecology & Obstetrics, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.

语种：

英文

关键词：

F-box proteins;Male germ cells;Male infertility;Spermatogenesis;Ubiquitylation

期刊：

细胞再生

ISSN：

2045-9769

年：

2024

卷：

期：

页码：

1-12

DOI：

10.1186/s13619-024-00196-9

基金类别：

This work was supported by National Natural Science Foundation of China (82371627), the Open Research Fund of Key Laboratory of Reproductive Medicine of Guangdong Province (2020B121206002902), the Natural Science Foundation of Fujian Province (2021J011346), and the Xiamen Medical and Health Guidance Project (3502Z20244ZD1021).

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation. They are the substrate-recognition subunits of SKP1-cullin1-F-box protein (SCF) E3 ligase complexes. Dysregulation of F‑box protein‑mediated proteolysis could lead to male infertility in humans and mice. The emerging studies revealed the physiological function, pathological evidence, and biochemical substrates of F-box proteins in the development of male germ cells, which urging us to revie...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility.

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问