Construction of Long-Wavelength Emissive Organic Nanosonosensitizer Targeting Mitochondria for Precise and Efficient In Vivo Sonotherapy

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成果类型：

期刊论文

作者：

Zhang, Xiangqian;Li, Chonglu;Zhang, Yi;Guan, Xiaofang;Mei, Longcan;...

通讯作者：

Sun, Yao(sunyaogbasp@ccnu.edu.cn)

作者机构：

[Feng, Huili; Zhang, Xiangqian; Deng, Ganzhen] Huazhong Agr Univ, Coll Anim Sci & Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.

[Feng, Guoqiang; Tu, Le; Zhang, Yi; Guan, Xiaofang; Mei, Longcan; Sun, Yao; Li, Chonglu] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.

[Li, Jie] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China.

[Tu, Le] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Peoples R China.

通讯机构：

[Yao Sun] K

Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079 China

语种：

英文

关键词：

cancer therapy;mitochondria-targeted;NIR-II region;organic nanosonosensitizer;sonodynamic therapy

期刊：

Advanced Functional Materials

ISSN：

1616-301X

年：

2022

卷：

期：

页码：

2207259-

DOI：

10.1002/adfm.202207259

基金类别：

X.Z., C.L., Y.Z., and X.G. contributed equally to this work. This work was supported by National Natural Science Foundation of China 22022404 and 22074050, supported by the Open Research Fund of State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS2214), the Open Research Fund of State Key Laboratory of Bioelectronics, the Fundamental Research Funds for the Central Universities (CCNU22QN007). All animal experiments were conducted in agreement with the guidelines of Institutional Animal Care and Use Committee (CCNU‐IACUC‐2011‐058). Finally, Y.S. thanks to the continuous and sincere support from his father (Wei Sun, 1957–2022). He has accompanied Y.S. from the Ph.D. student to a fresh professor.

机构署名：

本校为其他机构

院系归属：

化学学院

摘要：

As a modern biomedical therapeutic modality, sonodynamic therapy (SDT) presents unique advantages, including superior tissue penetration capability, temporal–spatial controllability, and negligible side effects. However, the bottlenecks of most organic sonosensitizers are their short emission wavelengths, strong phototoxicity, and unsatisfactory SDT effect, which undermines the precise fluorescence imaging-guided SDT in vivo. Here, a long-wavelength emissive and mitochondria-targeted organic nanosonosensitizer, named CCNU980 nanoparticles (NPs...

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Construction of Long-Wavelength Emissive Organic Nanosonosensitizer Targeting Mitochondria for Precise and Efficient In Vivo Sonotherapy

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