Functional single-walled carbon nanotubes \'CAR\' for targeting dopamine delivery into the brain of parkinsonian mice - 成果

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Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice

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成果类型：

期刊论文

作者：

Guo, Qing;You, Huihui;Yang, Xu;Lin, Bencheng;Zhu, Zhihong;...

通讯作者：

Li, Rui;Xi, Zhuge

作者机构：

[Shen, Shiping; You, Huihui; Yang, Xu; Li, Xiaoxiao; Zhao, Yun; Guo, Qing; Fan, Jianhua; Li, Rui; Deng, Lingfu; Mao, Lin] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

[Lin, Bencheng; Xi, Zhuge] Inst Hlth & Environm Med, Dali Rd, Tianjin 300050, Peoples R China.

[Zhu, Zhihong; Cheng, Haoyan; Zhang, Jiting] Cent China Normal Univ, Coll Phys Sci & Technol, Inst Nanosci & Nanotechnol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

[Li, Chang Ming; Lu, Zhisong] Southwest Univ, Fac Mat & Energy, Inst Clean Energy & Adv Mat, Tiansheng Rd, Chongqing 400715, Peoples R China.

[Li, Chang Ming] Suzhou Univ Sci & Technol, Inst Mat Sci & Devices, Suzhou 215011, Peoples R China.

通讯机构：

[Li, Rui] C

[Xi, Zhuge] I

Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

Inst Hlth & Environm Med, Dali Rd, Tianjin 300050, Peoples R China.

语种：

英文

期刊：

Nanoscale

ISSN：

2040-3364

年：

2017

卷：

期：

页码：

10832-10845

DOI：

10.1039/c7nr02682j

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372948, 21577045]; National Key Research and Development Program of China [2017YFC0702701]; Fundamental Research Funds for the Central Affiliated Universities [CCNU15A02028]

机构署名：

本校为第一且通讯机构

院系归属：

物理科学与技术学院

生命科学学院

摘要：

Current treatments for Parkinson's disease (PD) are limited, partly due to the difficulties posed by the blood brain barrier (BBB) when delivering drugs to the brain. Herein, we explore the feasibility and efficacy of functional single-walled carbon nanotubes 'CAR' (SWCNT-PEGs-Lf) which carry and target-deliver dopamine (DA) to the brain in PD mice for treatment. SWCNTs can penetrate the cell-membrane remarkably, with the characteristics including high drug-loading and pH-dependent therapeutic unloading capacities. It has been reported that polyethylene glycol (PEG)-coated SWCNTs could increas...

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Functional single-walled carbon nanotubes 'CAR' for targeting dopamine delivery into the brain of parkinsonian mice

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