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Selective transmembrane transport of A beta protein regulated by tryptophan enantiomers

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成果类型:
期刊论文
作者:
Zhu, Fei;Wang, Wenqian;Zhang, Fan;Dhinakaran, Manivannan Kalavathi;Wang, Yingqian;...
通讯作者:
Cheng, Jing;Li, Haibing
作者机构:
[Wang, Yingqian; Wang, Wenqian; Li, Haibing; Cheng, Jing; Li, HB; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Zhang, Fan; Wang, Rui] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
[Trautmann, Christina; Toimil-Molares, Maria Eugenia] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.
[Trautmann, Christina] Tech Univ Darmstadt, D-64287 Darmstadt, Germany.
通讯机构:
[Cheng, J; Li, HB] C
Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2021
卷:
57
期:
2
页码:
215-218
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21677058, 21772055, 21911530178]; National Key Research and Development Program of China [2018YFD0200102]; 111 ProjectMinistry of Education, China - 111 Project [B17019]; Self-determined research funds of CCNU from the colleges' basic research and operation of MOE
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
Tryptophan enantiomers (d/l-Trp) were introduced into artificial nanochannels to regulate the chiral selective transport of Aβ proteins. The l-Trp channel performs effectively selectivity for the transport of Aβ protein, which would provide a new perspective for the pathological studies of Alzheimer's disease. This journ...

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