Twelve 1,2,4 triazole derivatives containing arylthio or benzylthio groups are synthesized by the nucleophilic substitution reaction between 3 substituted 4 amino 5 mercapto 1,2,4 triazoles and substituted chlorobenzene or substituted benzyl chloride. All compounds synthesized are identified by 1H NMR and elemental analyses. The initial bioactive tests indicate that some compounds display ...