期刊论文、会议论文

Zhao, Junmin

英文

2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)

2156-1125

2013

386-391

IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM)

IEEE International Conference on Bioinformatics and Biomedicine-BIBM

DEC 18-21, 2013

Shanghai, PEOPLES R CHINA

[Zhao, Junmin] Cent China Normal Univ, Natl Engn Res Ctr E Learning, Wuhan, Peoples R China.^[Hu, Xiaohua;He, Tingting;Li, Peng;Zhang, Ming;XianjunShen] Cent China Normal Univ, Sch Comp, Wuhan, Peoples R China.^[Hu, Xiaohua] Drexel Univ, Coll Informat Sci & Engn, Philadelphia, PA USA.^[Zhao, Junmin] Henan Univ Urban Construct, Inst Comp Sci & Engn, Pingdingshan, Peoples R China.

IEEE, IEEE Comp Soc, Tongji Univ, IEEE Comp Soc Tech Comm Life Sci, China Acad Chinese Med Sci, Shanghai Assoc Syst Simulat

Li, GZ Kim, S Hughes, M McLachlan, G Sun, H Hu, X Ressom, H Liu, B Liebman, M

10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA

IEEE COMPUTER SOC

978-1-4799-1309-1; 978-1-4799-1310-7

10.1109/BIBM.2013.6732523

Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2011CDA034]; Program of Introducing Talents of Discipline to Universities [B07042]; Program of Introducing Talents of Discipline to University [B07042]; Project in the National Science & Technology Pillar Program in the Twelfth Five-year Plan Period [2012BAK24B01]; Major Project of State Language Commission in the Twelfth five-Year Plan Period [ZDI125-1]

本校为第一且通讯机构

Recent studies have shown that protein complex is composed of core and attachment proteins, and proteins inside the core are highly co-expressed. Based on this new concept, we reconstruct weighted PPI network by using gene expression data, and develop a novel protein complex identification algorithm from the angle of edge(PCIA-GeCo). First, we select the edge with high co-expressed coefficient as seed to form the preliminary cores. Then, the preliminary cores are filtered according to the weighted density of complex core to obtain the unique core. Finally, the protein complexes are generated b...