期刊论文

Li, Peng

英文

IEEE Transactions on NanoBioscience

1536-1241

2014

13

2

89-96

10.1109/TNB.2014.2317755

NSF of ChinaNational Natural Science Foundation of China (NSFC) [90920005, 61003192]; Major Project of State Language Commission in the Twelfth Five-year Plan Period [ZDI125-1]; Project in the National Science & Technology Pillar Program in the Twelfth Five-year Plan Period [2012BAK24B01]; Program of Introducing Talents of Discipline to UniversitiesMinistry of Education, China - 111 Project [B07042]; NSF of Hubei Province [2011CDA034]; self-determined research Funds of CCNU from the colleges' basic research and operation of MOE [CCNU10A02009, CCNU10C01005]

本校为第一且通讯机构

A novel algorithm based on Connected Affinity Clique Extension (CACE) for mining overlapping functional modules in protein interaction network is proposed in this paper. In this approach, the value of protein connected affinity which is inferred from protein complexes is interpreted as the reliability and possibility of interaction. The protein interaction network is constructed as a weighted graph, and the weight is dependent on the connected affinity coefficient. The experimental results of our CACE in two test data sets show that the CACE can detect the functional modules much more effectiv...