Role of Transient Receptor Potential Ion Channels and Evoked Levels of Neuropeptides in a Formaldehyde-Induced Model of Asthma in Balb/c Mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Yang;You, Huihui;Ma, Ping;Li, Li;Yuan, Ye;...

通讯作者：

Lai, Kefang

作者机构：

[Wu, Yang; Li, Li; Ye, Xin; Yuan, Ye; Yao, Hanchao; Li, Jinquan; You, Huihui; Yang, Xu; Liu, Xudong; Ma, Ping] Cent China Normal Univ, Sect Environm Biomed, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan, Peoples R China.

[Wu, Yang; Lai, Kefang; Chen, Ruchong] Guangzhou Med Univ, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China.

[Ma, Ping] Hubei Univ Sci & Technol, Coll Basic Med Sci, Xianning, Peoples R China.

通讯机构：

[Lai, Kefang] G

Guangzhou Med Univ, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China.

语种：

英文

关键词：

Asthma;Inflammation;Neuropeptides;Eosinophils;Cytokines;Enzyme-linked immunoassays;Transient receptor potential channels;Cell staining

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2013

卷：

期：

页码：

e62827

DOI：

10.1371/journal.pone.0062827

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51136002, 51076079]; State Key Laboratory of Respiratory Disease of China [2007DA780154F0906]; China Key Technologies RD Program [2012BAJ02B03]

机构署名：

本校为第一机构

院系归属：

生命科学学院

摘要：

Objective: Asthma is a complex pulmonary inflammatory disease characterized by the hyper-responsiveness, remodeling and inflammation of airways. Formaldehyde is a common indoor air pollutant that can cause asthma in people experiencing long-term exposure. The irritant effect and adjuvant effect are the two possible pathways of formaldehyde promoted asthma. Methodology/Principal Findings: To explore the neural mechanisms and adjuvant effect of formaldehyde, 48 Balb/c mice in six experimental groups were exposed to (a) vehicle control; (b) ovalbumin; (c) formaldehyde (3.0 mg/m(3)); (d) ovalbumin...

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Role of Transient Receptor Potential Ion Channels and Evoked Levels of Neuropeptides in a Formaldehyde-Induced Model of Asthma in Balb/c Mice

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