Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice

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成果类型：

期刊论文

作者：

Li, Jinquan;Chen, Yushan;Chen, Qiao Yi;Liu, Dan;Xu, Lang;...

通讯作者：

Zeng, Yan;Guo, Zhenzhong

作者机构：

[Cheng, Guirong; Xu, Lang; Li, Jinquan; Chen, Yushan; Zeng, Yan; Liu, Dan] Wuhan Univ Sci & Technol, Sch Med, Brain & Cognit Dysfunct Res Ctr, Wuhan 430065, Hubei, Peoples R China.

[Li, Jinquan; Guo, Zhenzhong] Wuhan Univ Sci & Technol, Med Coll, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Hubei, Peoples R China.

[Li, Jinquan; Zeng, Yan] Wuhan Univ Sci & Technol, Big Data Sci & Engn Res Inst, Wuhan 430065, Hubei, Peoples R China.

[Chen, Qiao Yi] NYU, Dept Environm Med, Sch Med, 57 Old Forge, Tuxedo Pk, NY 10987 USA.

[Yang, Xu] Cent China Normal Univ, Sect Environm Biomed, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Zeng, Yan; Guo, Zhenzhong] W

Wuhan Univ Sci & Technol, Sch Med, Brain & Cognit Dysfunct Res Ctr, Wuhan 430065, Hubei, Peoples R China.

Wuhan Univ Sci & Technol, Med Coll, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan 430065, Hubei, Peoples R China.

语种：

英文

关键词：

Allergic asthma;Calcitonin gene-related peptide;Ozone;Thymic stromal lymphopoietin;Transient receptor potential cation channel subfamily V member1

期刊：

Environmental Pollution

ISSN：

0269-7491

年：

2019

卷：

247

期：

Apr.

页码：

586-594

DOI：

10.1016/j.envpol.2019.01.091

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81302402, 31702247, 71774127, 81571095]; Hubei Province Key Laboratory of Occupational Hazard Identification and Control [OHIC2018Y01]

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本校为其他机构

院系归属：

生命科学学院

摘要：

Around the globe, worsening air pollution is spawning major public health and environmental concerns, especially in the poorest and most populous cities. As a major secondary air pollutant, ozone is a potential risk factor for exacerbated asthma, although the underlying mechanisms remain uncertain. In this study, we aim to investigate the role of ozone on asthma exacerbation using a classic asthmatic model with allergic airway inflammation by treating Balb/c mice with ovalbumin (OVA). Our study shows ozone exposure significantly exacerbated OVA-induced asthmatic phenotypes, including serum imm...

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Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice

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