期刊论文

Yang, G.-F.;Guo, J.

英文

ACS INFECTIOUS DISEASES

2373-8227

2022

8

7

1367-1375

10.1021/acsinfecdis.2c00259

This work was supported by the National Key Research and Development Program of China (2017YFA0505200), the National Natural Science Foundation of China (22177035, 21772056), the Wuhan Bureau of Science and Technology (2020020601012217), the self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (CCNU20TS016), and the Program of Introducing Talents of Discipline to Universities of China (111 program, B17019).

本校为第一机构

With the global pandemic of the new coronavirus disease (COVID-19), a safe, effective, and affordable mass-produced vaccine remains the current focus of research. Herein, we designed an adjuvant-protein conjugate vaccine candidate, in which the TLR7 agonist (TLR7a) was conjugated to S1 subunit of SARS-CoV-2 spike protein, and systematically compared the effect of different numbers of built-in TLR7a on the immune activity for the first time. As the number of built-in TLR7a increased, a bell-shaped reaction was observed in three TLR7a-S1 conjugat...