Intranuclear assembly of leucine-rich peptides for selective death of osteosarcoma cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Shuang*;Zhang, Qiuxin;Peng, Xingrao;Hu, Cong;Wang, Shaowei;...

通讯作者：

Liu, Shuang;Wang, SW;Sun, Y

作者机构：

[Wang, SW; Wang, Shaowei; Liu, Shuang] Chinese Acad Sci, Shanghai Inst Tech Phys, State Key Lab Infrared Phys, 420 Zhongshan Rd, Shanghai 200434, Peoples R China.

[Zhang, Qiuxin] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA.

[Peng, Xingrao; Sun, Yao] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

[Hu, Cong] Guilin Univ Elect Technol, Guangxi Key Lab Automat Detecting Technol & Instru, Guilin 541004, Peoples R China.

通讯机构：

[Wang, SW ; Sun, Y ; Liu, S] C

Chinese Acad Sci, Shanghai Inst Tech Phys, State Key Lab Infrared Phys, 420 Zhongshan Rd, Shanghai 200434, Peoples R China.

Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.

语种：

英文

期刊：

BIOMATERIALS SCIENCE

ISSN：

2047-4830

年：

2024

卷：

期：

页码：

1274-1280

DOI：

10.1039/d3bm02054a

基金类别：

National Natural Science Foundation of China [21904103, 22374055]; National Natural Science Foundation of China [(2023)0758]; Open Project Program of State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University; Open Project Program of Guangxi Key Laboratory of Automatic Detecting Technology and Instruments [YQ23205, SITP-NLIST-YB-2022-09]; Guilin University of Electronic Technology

机构署名：

本校为通讯机构

院系归属：

化学学院

摘要：

Herein, we show a pair of leucine-rich l- and d-phosphopeptides which self-assemble into twisting nanofibers, whose secondary structures contain a strong beta-sheet component after being dephosphorylated by alkaline phosphatase (ALP). While being incubated with ALP overexpressing osteosarcoma cells, both of the peptides self-assemble in the nuclei and induce cell death. The cell death involves multiple cell death modalities and occurs along with the disruption of cell membranes. Enzyme-instructed self-assembly (EISA) inhibits osteosarcoma cells and shows no side effect to other cells. In addit...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Intranuclear assembly of leucine-rich peptides for selective death of osteosarcoma cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问