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Heterogeneity in subjective cognitive decline in the Sino Longitudinal Study on Cognitive Decline(SILCODE): Empirically derived subtypes, structural and functional verification

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成果类型:
期刊论文
作者:
Fu, Zhenrong;Zhao, Mingyan;Li, Yuxia;He, Yirong;Wang, Xuetong;...
通讯作者:
Li, SY;Han, Y
作者机构:
[Fu, Zhenrong; Zhou, Zongkui] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Peoples R China.
[Fu, Zhenrong; Zhou, Zongkui] Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.
[Zhao, Mingyan] Tangshan Gongren Hosp, Dept Psychol, Tangshan, Peoples R China.
[Li, Yuxia] Tangshan Cent Hosp, Dept Neurol, Tangshan, Peoples R China.
[Han, Ying; Li, Yuxia] Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing, Peoples R China.
通讯机构:
[Han, Y ] C
[Li, SY ] B
Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Haikou 570228, Peoples R China.
Capital Med Univ, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China.
语种:
英文
关键词:
Alzheimer's disease;heterogeneity;neuroimaging;neuropsychology;subjective cognitive decline
期刊:
CNS Neuroscience & Therapeutics
ISSN:
1755-5930
年:
2023
卷:
29
期:
12
页码:
4032-4042
基金类别:
This work was supported by the National Natural Science Foundation of China (Grant No. 81972160, 82020108013, 82001773), and the National Science and Technology Innovation 2030 – Major program of “Brain Science and Brain‐Like Research” (Grant No. 2022ZD0211800). We are grateful to all the participants in this study. The Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort was supported by The National Key Research and Development Program of China (2016YFC1306300), National Natural Science Foundation of China (Grant 61633018, 81801052, 81430037), Beijing Nature Science Foundation (7161009), Beijing Municipal Commission of Health and Family Planning (PXM2019_026283_000002), Alzheimer's Research UK (ARUK‐SRF2017B‐1), Addenbrooke's Charitable Trust, Alzheimer's Society and The Lewy Body Society. The trial registration number is NCT03370744.
机构署名:
本校为第一机构
院系归属:
心理学院
摘要:
We empirically derived subgroups from the SILCODE SCD cohort using cluster analysis based on eight neuropsychological measures and examined patterns of structural and functional indices of each cluster‐derived subgroup relative to NC. Four SCD subgroups emerged: dysexecutive/mixed, neuropsychiatric, amnestic, and a cluster‐derived normal group. Abstract Aims We evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined ass...

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