This work was supported by the National Natural Science Foundation of China (Grant No. 81972160, 82020108013, 82001773), and the National Science and Technology Innovation 2030 – Major program of “Brain Science and Brain‐Like Research” (Grant No. 2022ZD0211800). We are grateful to all the participants in this study. The Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort was supported by The National Key Research and Development Program of China (2016YFC1306300), National Natural Science Foundation of China (Grant 61633018, 81801052, 81430037), Beijing Nature Science Foundation (7161009), Beijing Municipal Commission of Health and Family Planning (PXM2019_026283_000002), Alzheimer's Research UK (ARUK‐SRF2017B‐1), Addenbrooke's Charitable Trust, Alzheimer's Society and The Lewy Body Society. The trial registration number is NCT03370744.