Specific extraction of nucleic acids employing pillar[6]arene-functionalized nanochannel platforms

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成果类型：

期刊论文

作者：

Li, Yu;Li, Wenjie;Xu, Weiwei;Huang, Jinmei;Sun, Zhongyue*;...

通讯作者：

Sun, Zhongyue;Liao, Tangbin;Xu, Chuanlai;Cheng, Jing;Li, Haibing

作者机构：

[Li, Yu; Xu, Chuanlai; Li, Haibing; Cheng, Jing] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.

[Li, Yu; Li, Wenjie; Huang, Jinmei; Li, Haibing; Xu, Weiwei; Cheng, Jing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.

[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.

[Liao, Tangbin] Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China.

[Kovaleva, Elena G.] Ural Fed Univ, Dept Technol Organ Synth, Mira St 28, Ekaterinburg 620002, Russia.

通讯机构：

[Zhongyue Sun; Tangbin Liao; Chuanlai Xu; Jing Cheng; Haibing Li] S

School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

语种：

英文

期刊：

Chemical Communications

ISSN：

1359-7345

年：

2022

卷：

期：

页码：

9278-9281

DOI：

10.1039/d2cc02693g

基金类别：

Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan University [SKLF-KF-202103]; National Key Research and Development Program [2021YFA0716702]; National Natural Science Foundation of China [22071074, 21772055]; Health Commission of Hubei Province [WJ2021M213]; 111 Project [B17019]; Self-determined research funds of CCNU from the colleges' basic research and operation of MOE

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本校为其他机构

院系归属：

化学学院

摘要：

The rapid extraction of high-purity nucleic acids from complex biological samples using conventional methods is complicated. Therefore, in this study, glycine-pillar[6]arene (Gly-P6)-functionalized tapered nanochannels were constructed using 32-mer single-stranded E. coli DNA (ssDNA) as a model sequence, which can selectively transport ssDNA by multiple noncovalent forces (transport flux of 2.65 nM cm−2 h−1) under the interference of amino acids and other substances. In view of these prospective results, the selective transport of nucleic aci...

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Specific extraction of nucleic acids employing pillar[6]arene-functionalized nanochannel platforms

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