National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20872043, 2107269, 21002036]; National Basic Research Program of ChinaNational Basic Research Program of China [2011CB808600]; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A highly enantioselective cascade reaction of benzotriazoles with nitroolefin-containing enonates catalyzed by a base/acid bifunctional organocatalyst has been developed. This cascade sequence affords efficient access to densely functionalized chiral chromans with a quaternary stereogenic center in high yield (up to 91%) with excellent enantioselectivity (up to 96% ee) and diastereoselectivity (up to 96:4 dr). The reaction itself features simple experimental procedures under benign conditions and is completely at...