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Angelica injection reduces cognitive impairment during chronic cerebral hypoperfusion through brain-derived neurotrophic factor and nerve growth factor

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成果类型:
期刊论文
作者:
Zheng, Ping;Zhang, Junjian*;Liu, Hanxing;Xu, Xiaojuan;Zhang, Xiaolian
通讯作者:
Zhang, Junjian
作者机构:
[Liu, Hanxing; Zheng, Ping; Zhang, Junjian] Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan 430071, Peoples R China.
[Zheng, Ping] Cent China Normal Univ, Dept Psychol, Wuhan 430079, Peoples R China.
[Xu, Xiaojuan] Grand Valley State Univ, Dept Psychol, Allendale, MI 49401 USA.
[Zhang, Xiaolian] Wuhan Univ, Dept Immunol, Wuhan 430071, Peoples R China.
通讯机构:
[Zhang, Junjian] W
Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan 430071, Peoples R China.
语种:
英文
关键词:
Chronic cerebral hypoperfusion;bilateral common carotid artery occlusion;2-vessel occlusion (2-VO);spatial learning;brain-derived neurotrophic factor (BDNF);nerve growth factor (NGF);reverse transcription-polymerase chain reaction (RT-PCR);western blotting
期刊:
CURRENT NEUROVASCULAR RESEARCH
ISSN:
1567-2026
年:
2008
卷:
5
期:
1
页码:
13-20
机构署名:
本校为其他机构
院系归属:
心理学院
摘要:
The current study investigated whether chronic cerebral hypoperfusion produced by permanent bilateral common carotid artery occlusion (2-vessel occlusion (2-VO)) induced cognitive impairment and whether angelica injections alleviated the impairment. Furthermore, the study examined whether 2-VO altered the expression patterns of brainderived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus of rats and whether angelica injections attenuated the alteration. Rats were divided into four groups to receive either 2-VO surgery or sham surgery followed by either angelica inje...

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