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The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway

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成果类型:
期刊论文
作者:
Li, Jingyi;Zhang, Ming;Pei, Yiying;Yang, Qifang;Zheng, Lihua;...
通讯作者:
Wei Yang<&wdkj&>Lei Liu
作者机构:
[Sun, Ying; Li, Jingyi; Wang, Guannan; Zheng, Lihua; Pei, Yiying; Yang, Qifang] National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China
[Zhang, Ming] Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China
[Yang, Wei] Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China. Electronic address: wyang2002@jlu.edu.cn
[Liu, Lei] National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China. Electronic address: liul905@nenu.edu.cn
通讯机构:
[Wei Yang] J
[Lei Liu] N
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China<&wdkj&>Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China
语种:
英文
关键词:
Alkaloid;Antidepressant;BDNF;Sophora Alopecuroides L.
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2023
卷:
316
页码:
116723
机构署名:
本校为其他机构
院系归属:
生命科学学院
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Depression has become a global public health problem and the development of new highly effective, low-toxicity antidepressants is imminent. Sophora alopecuroides L. is a common medicinal plant, which has therapeutic effect on central nervous system diseases. AIM OF THE STUDY: In this study, the antidepressant effect of total alkaloids (ALK) isolated from Sophora alopecuroides L. was explored and the mechanism was further elucidated. MATERIALS AND METHODS: A primary neuronal injury model was established in vitro by corticosterone. ICR mice were then selected to c...

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