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Synthesis and antitumor activity of ureas containing pyrimidinyl group

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成果类型:
期刊论文
作者:
Jin, Chuanfei;Liang, Yong-Ju;He, Hongwu*;Fu, Liwu
通讯作者:
He, Hongwu
作者机构:
[He, Hongwu; Jin, Chuanfei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
[Liang, Yong-Ju; Fu, Liwu] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China.
[He, Hongwu] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[He, Hongwu] C
Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
4,6-Dimethy-2-(methylsulfonyl)pyrimidine;Cytotoxicity;Urea
期刊:
European Journal of Medicinal Chemistry
ISSN:
0223-5234
年:
2011
卷:
46
期:
1
页码:
429-432
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20772042]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A novel series of ureas containing pyrimidinyl group were designed and synthesized. Some of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that introduction of a sulfide bridge between phenyl and pyrimidinyl rings would be c...

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