Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety

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成果类型：

期刊论文

作者：

He, Junbo;Wang, Xiaoguo;Zhao, Xiaoqin;Liang, YongJu;He, Hongwu*;...

通讯作者：

He, Hongwu

作者机构：

[He, Hongwu; He, Junbo; Wang, Xiaoguo] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesiticide & Chem Biol, Wuhan 430079, Peoples R China.

[Liang, YongJu; Zhao, Xiaoqin; Fu, Liwu] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol S China, Guangzhou 510060, Guangdong, Peoples R China.

[He, Hongwu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesiticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

通讯机构：

[He, Hongwu] C

Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesiticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.

语种：

英文

关键词：

Antitumor activity;Quinazoline;Synthesis;Thiosemicarbazide

期刊：

European Journal of Medicinal Chemistry

ISSN：

0223-5234

年：

2012

卷：

页码：

925-930

DOI：

10.1016/j.ejmech.2012.06.003

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2010CB126100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [20772042, 21172090]; PCSIRTProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT0953]; Science and Technological Project of Guangzhou City [12C32061587]

机构署名：

本校为第一且通讯机构

院系归属：

化学学院

摘要：

Series of novel derivatives of quinazoline containing thiosemicarbazide moiety 5 and 9 have been synthesized and tested for their antitumor activities in vitro against a panel of five human cancer cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various cancer cells. From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their...

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Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety

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