The paper analyses mainly the Middle-Route Water Transfer from South to North Project gives rise to environmental influences on the region water being transferred out. It also studies that relation between change of water resource and material circulation, water transfer modifies original hydrologic situation—natusral environmental change—social economi cchange, and negative benifit during water transfer being put into practice. Then some countermeasures should be adopted are put forward when the Middle-Route Water Transfer from S...