期刊论文

中文

华中师范大学学报(自然科学版)

1000-1190

2007

41

4

546-548

10.19603/j.cnki.1000-1190.2007.04.017

国家自然科学基金资助项目（20603010）.；

本校为第一机构

以茶碱与氟里昂反应合成出一种新的化合物．对二氟甲基化反应条件进行了改进，在反应体系中加入金属钾以除去易引起副反应的水，使反应产率从30％提高到86％．探讨了含氮杂环化合物的二氟甲基化的反应机理、合成条件、分子结构对反应的影响，所合成的物质用IR，UV，^1HNMR，^13F NMR和MS进行了分析表征．

This present paper describes theophylline reacting with chlorodifluoromethane to produce a new compound. The reaction conditions of difluromethylation were improved. After the water, which is easy to lead to by-reactions,was got rid of by adding potassium in the reacting system, the yields were increased from 30% to 86%. The reaction mechanism, reaction conditions and the molecular structure＇s influence were discussed. The products were charact...