To investigate the role of extracellular somatostatin（SST） in insulin secretion from rat pancreatic β cells. Primary cultures of pancreatic β cells were prepared. The cells were loaded by incubation with fura2-AM in the bath solution. Intracellular Ca^2＋ （[Ca^2＋ ]i） was measured by dual-wavelength excitation （350/380 nm） microfluorometry using fura-2 as the Ca^2＋ indicator. The membrane current and membrane capacitance （Cm） were examined by using the whole-cell patch clamp recording technique. Mem- brane capacitance measurements we...
