期刊论文

中文

华中师范大学学报(自然科学版)

1000-1190

2013

47

2

246-249

10.19603/j.cnki.1000-1190.2013.02.023

湖北省教育厅科学技术研究项目（D20122803）.

本校为其他机构

为了研究毒死蜱对生物体的氧化损伤,以昆明小鼠为受试体,毒死蜱按3、6和12 mg/kg 3个剂量水平,灌胃染毒小鼠,每天1次,连续7d,测定小鼠肺的脏器系数比,以肺组织匀浆液测定活性氧(reactive oxygen species,ROS)、还原型谷胱甘肽(glutathione,GSH)和丙二醛(Malondialdehyde,MDA)的含量.实验结果表明:随着毒死蜱染毒剂量的升高,ROS和MDA含量逐渐上升,肺的脏器系数比和GSH含量逐渐降低,各指标呈一定的剂量-效应关系.染毒剂量≥6 mg/kg时,GSH和MDA含量有显著差异(P＜0.05)；染毒剂量≥12mg/kg时,ROS含量有显著差异(P＜0.05),肺的脏器系数比、GSH和MDA含量有极显著差异(P＜0.01).说明较高剂量的毒死蜱可...

Chlorpyrifos is one kind of efficient, broad-spectrum organic phosphorus insecticide. This study aims at observing the oxidative stress effects of chlorpyrifos on organisms. Kunming mice were orally administrated with chlorpyrifos daily for seven days at the concentration of 3, 6 and 12 mg/kg respectively , Afterwards, organ coefficient ratio of mouse lung were measured, the contents of ROS （reactive oxygen species） 、GSH （glutathione） and MDA（Malondialdehyde） in the lung tissue homogenates were measured. The experimental results showed t...