期刊论文

Synthesis and fungicidal activity of 2-methylpropan-2-aminium O-alkylα-(substituted aniline)alkylphosphonate

中文

华中师范大学学报(自然科学版)

1000-1190

2018

05

650-654+704

10.19603/j.cnki.1000-1190.2018.05.010

国家自然科学基金项目（21472062）；

本校为第一机构

为了研究α-（取代苯氨基）烃基膦酸酯衍生物的结构活性关系，以取代苯胺和取代苯甲醛为起始原料，经高氯酸镁催化，与亚磷酸二甲酯反应得到α-（取代苯氨基）烃基膦酸酯1，再与叔丁胺反应合成了11个未见文献报道的O-甲基α-（取代苯氨基）烃基膦酸特丁基铵2.通过1H NMR，13 C NMR，IR，MS和元素分析对所合成的化合物进行了结构表征.初步的杀菌活性测试结果表明：大多数目标化合物具有较好的杀菌活性，并且其对真菌的防治效果优于对细菌的防治效果.在500 mg/mL的剂量下，化合物2b和2f对番茄晚疫病的防效达到75%以上，略低于对照药剂烯酰吗啉.

For the purpose of studying the structure-activity relationship ofα-(substituted aniline)alkylphosphonate derivatives,a series of novelα-(substituted aniline)alkylphosphonates(1)was synthesized with substituted aniline and substituted benzaldehydes as starting materials reacting with dimethyl phosphite catalyzed by magnesium perchlorate.Compounds 1 reacted with t-Bu-NH 2 to gain 2-methylpropan-2-aminium O-alkylα-(substituted aniline)alkylphosphonate(2).The structures of compounds 2 were confirmed by 1H NMR,13 C NMR,IR,MS and elemental analys...