Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip.

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成果类型：

期刊论文

作者：

Li, Yan;Wu, Yang;Liu, Yan;Deng, Qi-Hong;Mak, Michael*;...

通讯作者：

Mak, Michael;Yang, Xu

作者机构：

[Liu, Yan; Wu, Yang; Li, Yan] Wuhan Polytech Univ, Coll Food Sci & Engn, Key Lab Deep Proc Major Grain & Oil, Chinese Minist Educ, Wuhan 430023, Hubei, Peoples R China.

[Li, Yan; Mak, Michael] Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

[Deng, Qi-Hong] Cent S Univ, XiangYa Sch Publ Hlth, Changsha 410083, Hunan, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Lab Environm Biomed, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.

通讯机构：

[Mak, Michael] Y

[Yang, Xu] C

Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

Cent China Normal Univ, Lab Environm Biomed, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

期刊：

Nanoscale

ISSN：

2040-3364

年：

2019

卷：

期：

页码：

15537-15549

DOI：

10.1039/c9nr03622a

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21607117]

机构署名：

本校为通讯机构

院系归属：

生命科学学院

摘要：

Inhaled atmospheric nanoparticles (ANPs) can migrate into human blood vessels. However, the exact pathogenesis has not yet been well elucidated. In this study, a perfusable 3D human microvessel network was constructed in a microfluidic device. This functional 3D micro-tissue partly mimicked the physiological response of human vessels. Intravascular nanoparticles tend to adsorb proteins to form a protein corona. Based on this pathological response, vessel permeability and vasoconstriction resulting from ANP stimulation might be related to vascul...

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Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip.

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