期刊论文

Chen, Jia-Rong;Xiao, Wen-Jing

英文

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1433-7851

2017

56

32

9527-9531

10.1002/anie.201704690

We are grateful to the NNSFC (21472058, 21472057, 21622201, and 21232003), the Distinguished Youth Foundation of Hubei Province (2016CFA050), CCNU (CCNU16JCZX02 and CCNU17TS0011), and the Program of Introducing Talents of Discipline to Universities of China (111 Program, B17019) for support of this research.

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A visible-light-driven radical-mediated strategy for the in situ generation of aza-ortho-quinone methides from 2-vinyl-substituted anilines and alkyl radical precursors is described. This process enables an efficient multicomponent reaction of 2-vinylanilines, halides, and sulfur ylides, and has a wide substrate scope and good functional group tolerance. Treatment of the cycloaddition products with a base leads to densely functionalized indoles in a single-flask o...