期刊论文

Chen, Jia-Rong

英文

ChemCatChem

1867-3880

2019

11

21

5300-5305

10.1002/cctc.201901695

NNSFCNational Natural Science Foundation of China (NSFC) [91856119, 21971081, 21622201, 21820102003, 21772053]; Science and Technology Department of Hubei Province [2016CFA050, 2017AHB047]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]

本校为第一且通讯机构

Sulfones and alkylnitriles play a significant role in both organic and medicinal chemistry, as versatile synthetic building blocks and privileged pharmacophores in many natural products and bioactive compounds. Herein, a room-temperature, copper-catalyzed radical cross-coupling of redox-active cycloketone oxime esters and sulfinate salts is described for the first time. Key to the success of this process involves catalytic generation of a cyclic iminyl radical and ensuing ring-opening C−C bond cleavage. The resultant cyanoalkyl radical is then...