This work is supported by National Natural Science Foundation of China under No. 12175080, also financially supported by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE under No. CCNU22JC009.
机构署名：
本校为第一且通讯机构
院系归属：
物理科学与技术学院
摘要：
Optogenetics as an emerging technology can eliminate spiral waves in myocardial tissue. The heat generated during illumination of myocardial tissue is an overlooked influence. Even small fluctuations in temperature may affect the action potentials of cardiomyocyte. In this paper, a minimal ventricular model and a simplified model of optogenetics are employed to study the effects of heat generation by illumination on elimination of spiral waves. The Luo-Rudy model and Channelrhodospin-2 light-sensitive ion channel model are used to validate our conclusions. We induce drift of spiral waves throu...
