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Uracil hydrazones: design, synthesis, antimicrobial activities, and putative mode of action

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成果类型:
期刊论文
作者:
Zhou, Huan;Li, Qing X.;Zeng, Lei;Cao, Congwang;Zhang, Tuotuo;...
通讯作者:
Zhou, Yuan;He, HW
作者机构:
[He, Hongwu; Zhang, Tuotuo; Cao, Congwang; Zhou, Huan; Zeng, Lei; Zhou, Yuan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.
[Li, Qing X.] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI USA.
[He, Hongwu; He, HW; Zhou, Yuan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[He, HW ; Zhou, Y] C
Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
语种:
英文
关键词:
synthesis;uracil hydrazone;antibacterial;antifungal;action mechanism
期刊:
Pest Management Science
ISSN:
1526-498X
年:
2024
卷:
80
期:
2
页码:
414-425
基金类别:
The authors acknowledge Prof. Lin Zhou, Henan Agricultural University, for testing the <italic>in vitro</italic> and <italic>in vivo</italic> activities of the compounds against <italic>Sclerotium rolfsii</italic>. This work was supported in part by the Na [21472062, 21907035]; National Natural Science Foundation of China [HAW05020H, HAW05044R]; United States Department of Agriculture
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
摘要:
A series of uracil hydrazones were designed and assessed for their antimicrobial properties. IV‐B20 showed effective and broad‐spectrum activity. IV‐B20 induced oxidative damage and promoted the leakage of cellular contents. Abstract BACKGROUND Crop diseases caused by plant pathogenic fungi and bacteria have led to substantial losses in global food production. Chemical pesticides have been widely used as a primary means to mitigate these issues. Nevertheless, the persistent and excessive use of pesticides has resulted in the emergence of mic...

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