Endogenous formaldehyde is a memory-related molecule in mice and humans

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成果类型：

期刊论文

作者：

Ai, Li;Tan, Tao;Tang, Yonghe;Yang, Jun;Cui, Dehua;...

通讯作者：

Tong, Zhiqian

作者机构：

[Fei, Xuechao; He, Rongqiao; Di, Yalan; Bai, Shangying; Tong, Zhiqian; Wang, Xiaoming; Ai, Li] Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

[Fei, Xuechao; He, Rongqiao; Di, Yalan; Bai, Shangying; Tong, Zhiqian; Wang, Xiaoming; Ai, Li] Capital Med Univ, Ctr Brain Disorders Res, Beijing 100069, Peoples R China.

[Tan, Tao] SUNY Buffalo, Sch Med & Biomed Sci, Dept Physiol & Biophys, Buffalo, NY 14214 USA.

[Tan, Tao] Sichuan Prov Hosp Women & Children, Chengdu 610000, Sichuan, Peoples R China.

[Wang, Weishan; Lin, Weiying; Tang, Yonghe] Jinan Univ, Inst Fluorescent Probes Biol Imaging, Sch Chem & Chem Engn, Sch Mat Sci & Engn, Jinan 250022, Shandong, Peoples R China.

通讯机构：

[Tong, Zhiqian] C

Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China.

Capital Med Univ, Ctr Brain Disorders Res, Beijing 100069, Peoples R China.

语种：

英文

期刊：

Communications Biology

ISSN：

2399-3642

年：

2019

卷：

期：

DOI：

10.1038/s42003-019-0694-x

基金类别：

Chinese Institute for Brain Research, Beijing (CIBR, Beijing) [Z181100001518004]; NSFCNational Natural Science Foundation of China (NSFC) [61625102, 61827810, 81571044]; 973 ProgramNational Basic Research Program of China [2015CB856402]; Beijing Natural Science Foundation of ChinaBeijing Natural Science Foundation [7172022]; Scientific Research Common Program of Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [KM201510025014]; Major Projects Fund of Beijing Institute for Brain Disorders [ZD2015-08]; startup fund of Advanced Innovation Center for Human Brain Protection [1172120205]; HTRDC [2016YFC1305903, 2016YFC1306302]

机构署名：

本校为其他机构

院系归属：

生命科学学院

摘要：

Gaseous formaldehyde is an organic small molecule formed in the early stages of earth’s evolution. Although toxic in high concentrations, formaldehyde plays an important role in cellular metabolism and, unexpectedly, is found even in the healthy brain. However, its pathophysiological functions in the brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid formaldehyde generation from mitochondrial sarcosine dehydrogenase (SARDH). We find that elevated formaldehyde levels facilitate spatia...

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Endogenous formaldehyde is a memory-related molecule in mice and humans

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