Optically active α-substituted phenoxyacetyloxy and aroyloxy phosphonates have been synthesized via catalytic asymmetric hydrogenation of the corresponding prochiral α, β- unsaturated phosphonates using Rh (I)/(R, R)-Me-DuPhos as the catalyst in methanol at 18℃. The asymmetric hydrogenation reaction exhibits excellent enantioselectivity with enantiom...
